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Hepatology 44 , 788794

For example, acetylcholine modulates dopaminergic signaling in the striatum, an area considerably impacted in Parkinson's disease

Additional genetic polymorphisms occurring in choline and one-carbon metabolic pathways may alter the dietary requirement for choline and thus increase the likelihood of developing signs of deficiency when choline intake is inadequate (9, 20, 21)

Yes, when taken in recommended doses

171,202 Since GKT137831 achieved satisfactory renal protection in various CKD animal models, a multicenter, randomized, placebo-controlled trial about GKT137831 was conducted in type 1 diabetes-related kidney disease patients