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34 In addition, it was reported that RUCAM, the internationally most widely used scale for the diagnosis of DILI, was used in only two of eight recent RCTs in DILI

It has been shown that the main metabolites of chlorogenic acid formed in the large intestine, e.g., dihydrocaffeic acid, dihydroferulic acid, dihydroxyhippuric acid, have antioxidant properties and can reduce levels of pro-inflammatory cytokines such as IL-1, IL-6, MCP-1

Ham BJ, Sung Y, Kim N, Kim SJ, Kim JE, Kim DJ, et al

Upregulation of Bax and caspase-3, downregulation of Bcl-2 and BDNF, along with increased GFAP immunoreactivity, indicated enhanced neuronal apoptosis and astrocyte activation