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Statistical significance was determined using a One-sample T-test with each column compared to 1.0 ( a

SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

10.1038/s41568-021-00383-9 64 LiangK

J Exp Med 192:10011014 Kehrer JP (2000) The Haber-Weiss reaction and mechanisms of toxicity

Oncogene 29:14751485