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Accordingly, the lack of effect of the dose of D-cysteine used in this study (250 mol/kg, = 30.3 mg/kg per each injection) may be because it does not enter brain cells involved in establishing physical dependence to morphine in sufficient quantities to exert meaningful cell-signaling events that can countermand the processes underlying the development of dependence

Iron chelators such as deferoxamine (DFO), deferiprone, and ciclopirox chelate iron and prevent the propagation of lipid peroxidation by limiting the Fenton reaction [17]

However, a comprehensive system-wide understanding of its anticancer mechanims remains unclear

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Structure and function of the xenobiotic substrate binding site of a glutathione S-transferase as revealed by X-ray crystallographic analysis of product complexes with the diastereomers of 9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene