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Office of Dietary Supplements, National Institutes of Health Available at: Updated March 11, 2020

Endometriosis is caused by mechanisms including: Chronic inflammation Estrogen dominance or impaired estrogen clearance Immune dysregulation Oxidative stress Gut and microbiome imbalance Nervous system sensitization and pain signaling That means that the most effective supplements for endometriosis tend to fall into a few key categories: Anti-inflammatory supplements for endometriosis: A big trigger of endometriosis is chronic, systemic inflammation, not just inflammation during menstruation

doi:10.1001/virtualmentor.2013.15.11.hlaw1-1311

Int Rev Neurobiol 59:273296

Abbreviations AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis AMPK: AMP-activated protein kinase BBB: Blood-brain barrier CNS: Central nerve system EAAT-1: Excitatory amino acid transporter 1 EAE: Experimental allergic encephalomyelitis H 2 O 2 : Hydrogen peroxide MCI: Mild cognitive impairment MS: Multiple sclerosis MSU: Monosodium urate mTOR: Mammalian target of rapamycin NO: Nitric oxide ONOO : Peroxynitrite PD: Parkinsons disease RNS: Reactive nitrogen species ROS: Reactive oxygen species SCI: Spinal cord injury SOD: Superoxide dismutase TFEB: Transcription factor EB TLR: Toll-like receptor UA: Uric acid VEGF: Vascular endothelial growth factor XO: Xanthine oxidase References Burtscher J, Millet GP, Place N, Kayser B, Zanou N