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It can be produced by the body itself, but is also influenced by nutrition, stress levels, sleep quality and exposure to environmental stressors

A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

[DOI] [PubMed] [Google Scholar] 46.Harris H.R., Costenbader K.H., Mu F., Kvaskoff M., Malspeis S., Karlson E.W., Missmer S.A

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Support with Diet: Eat plenty of sulfur-rich vegetables and manage oxidative stressors