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What to monitor Visible changes: Skin texture and tone Fine line depth Hair density and quality Wound healing speed Subjective factors: Energy levels Sleep quality General sense of wellbeing Side effects: Injection site reactions Skin flushing Fatigue (especially early in use) Photograph yourself in consistent lighting at baseline and every 4 weeks

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and C.B.) assessed risk of bias in group matching based on variables using the NewcastleOttawa quality assessment for casecontrol studies (Stang 2010), and where there was a dispute a third senior supervising author checked the study information (Supplemental Table 1)

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