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Purification was performed by FLASH chromatography using a PLC 2020 Personal Purification System (Gilson) with a PuriFlash column (130 21 mm, SIHP-JP, 30 m) and a solvent mixture of n-hexane and ethyl acetate (2:1, v/v)

However, routine clinical applications remain limited because of the potential adverse effects [70]

In general: 48 weeks: Improvements in overall skin glow and radiance may become noticeable

Ondansetron treatment (10 mg/kg) partially ameliorated disease-induced histopathological changes, reducing hepatic steatosis and modestly preserving the liver architecture, although some hepatocellular ballooning and necrosis were still evident (black arrows) ( C )

Moreover, we revealed the critical involvement of the renal circadian clock in the systemic control of tissue carnitine levels