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In this pathway, apoptosis is trigger by the release of cytochrome C (cyto C) from mitochondria, which further induces the activation of caspase cascades 99

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17(12): CR677CR682.

A significant number of studies included individual case reports and case series, underscoring the importance of the Roussel Uclaf Causality Assessment Method (RUCAM) as our primary tool for identifying DILI attributed to specific agents

141 Similarly, Li et al designed a nanoparticle system modified with pardaxin peptides that induces ER stress via photodynamic/photothermal therapy, triggering immunogenic cell death and demonstrating enhanced antitumor efficacy