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In this model, inflammation drives a massive upregulation of proangiogenic factors, which overwhelms the antiangiogenic mechanisms of the cornea and results in a secondary ingrowth of both blood and lymphatic vessels from the limbal area into the corneal center 15

doi: 10.1111/jpi.12559 31 LombardoFGiorginiEGioacchiniGMaradonnaFFerrarisPCarnevaliO

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In contrast, Hmox1 RNA and protein levels progressively increased to become higher than in WT mice at ~36 and 52 h (Figure 7a)