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This dual-delivery strategy effectively co-localized antiPD-1 antibodies and curcumin within tumors and demonstrated superior therapeutic efficacy in both in vitro and in vivo models ( 5 Conclusion and future perspectives Natural metabolism-regulating agents have emerged as promising adjuvant strategies in cancer immunotherapy due to their ability to reprogram metabolic pathways and restore antitumor immunity

doi: 10.1016/j.ajpath.2011.02.035 255 Ramezani-MoghadamMWangJHoVIseliTJAlzahraniBXuAet al

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This complex induces mitochondrial outer membrane permeabilization via BAK/BAX dimerization, releasing cytochrome c to trigger apoptosis [355]