glutathione and mitochondrial function (GSH), a powerful intracellular antioxidant, plays a SLC25A39 is necessary for mitochondrial

5.2.4 Ferroptosis suppressor protein 1 and coenzyme Q10 pathway FSP1 possesses NAD(P)H oxidoreductase activity and reduces CoQ to ubiquinol (CoQH2), which inhibits lipid peroxidation and ferroptosis by trapping lipid peroxidation free radicals (77, 78)

A growing list of molecular targets, including PKD [118], PARP1 [25], Padi4 [46], HMGB2 [44], WTAP [42], METTL3 [66], SP2509 [80], BRD4770 [72], LDHA [71], KLF15 [89] and others, further expands the therapeutic landscape of ferroptosis regulation and intervention

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However, it remained possible that normal levels of TrxR2 protein, though perhaps lower than normal levels of TrxR1 protein (see above), might be sufficient to compensate for loss of TrxR1 without an associated increase in mRNA levels

Anne-Galle Planson: Understanding the specificities of E