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The AUCs of ten-fold cross validation, five-fold cross validation, leave-one-subject-out cross-validation and ten-fold cross-validation were 0.92, 0.85, 0.87 and 0.84 respectively

In another embodiment, the assay is a cell-based assay comprising contacting a cancer cell with a cytotoxic T cell, monocyte and/or macrophage and a test agent, and determining the ability of the test agent to modulate the copy number, amount and/or activity of at least one target listed in table 1 and/or table 2 and/or modulate an immune response, e.g., by measuring direct or indirect parameters as described below

Age has a large impact on the severity of COVID-19 symptoms, where older individuals are at an increased risk compared to younger individuals

Yadav R, Shukla G, Goyal V, Singh S, Behari M

Briefly, there are four possible mechanisms of CRPC development: 1) Increased sensitivity of the AR to its agonists, 2) AR mutations that render the receptor responsive to alternate, non-androgen ligands, 3) ligand-independent AR activation, and 4) AR-independent mechanisms (Figure 5)