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Vitamin B12 deficiency in DNA synthesis reduction is explained by the folate trapping theory as methyl-tetrahydrofolate.(...) methionine synthase cannot be activated and folate remains as methyl-FH4, which also causes a functional folate deficiency, thus explaining megaloblastic anemia." SOURCE: Interrelation of Vitamin B12 and Folic Acid

10.1007/s10620-010-1307-1 Mutlu-Trkolu , Erbil Y, ztezcan S, Olga V, Token G, Uysal M: The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats