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406 Therefore, endogenous GLP-1R signaling in astrocytes plays a critical role in maintaining mitochondrial homeostasis and is dependent on FGF21 to effectively regulate glucose metabolism

As of mid-2026, neither cagrilintide nor retatrutide is approved by the FDA or EMA for any indication

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These sample sizes cannot detect modest effects or uncommon harms

Benefits of Ozempic & Wegovy (Semaglutide) Reduced appetite and fewer cravings Improved portion control Gradual, medically supervised weight loss Potential improvement in metabolic markers Support for long-term lifestyle changes Individual results vary