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257 In contrast, the negative regulators of the JAK/STAT pathway, CIS, SOCS1 and SOCS3 were found frequently downregulated or lost in HCC, thus resulting in continuous activation of the pathway and HCC progression

10.1016/j.immuni.2017.11.016 27 CollissonE

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Moreover, the high complexity and heterogeneity of tumor metabolism, along with its close interaction with the TME, have collectively driven the evolution of treatment paradigms from single-agent approaches to multidimensional synergistic strategies

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