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Furthermore, the use of animal models is limited for ethical reasons by increasingly stringent regulations

Preclinical studies show neuroprotective effects in models of traumatic brain injury, spinal cord compression, and peripheral nerve transection

Furthermore, clinical trials involving the Shoemaker Protocol utilized repetitive "re-exposure" studies

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[,,,] Mechanistically, Them2 limits the rates of fatty acid oxidation in the skeletal muscle, thus, decreases the demand by the skeletal muscle for fatty acids in the form of secreted hepatic VLDL TG