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Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

We found that treatment with NAC (500 M) alone had no effect on ROS levels in No AMD cells (Figure 1(a)) but caused a significant decrease in basal ROS content (25%) in AMD ( p = 0.0009) cells compared to no treatment controls (Figure 1(b))

The 2-NTE has previously been shown to promote phosphorylation of -T172 [114], raising the possibility these putative mTORC1 substrates modulate AMPK activity