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Contributing factors include: Lack of trained neurologists or movement disorder clinics

DSIP contains a tryptophan residue that makes it more light-sensitive, so extra attention to UV protection is warranted

Glycated RBCs are also more sensitive to oxidative stress, which injures the lipid bilayer and shortens the life span of the cell

Furthermore, BSO-mediated GSH depletion oxidatively modified the tuberous sclerosis protein complex (TSC) consisting of hamartin (TSC1), tuberin (TSC2), and TBC1 domain family member 7 (TBC1D7) which are critical negative regulators of mTORC1