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Data and median represent three pooled experiments (n = 15)

In gingival fibroblasts, CAPE suppresses LPS-induced production of IL-6, IL-8, iNOS, COX-2, TLR4/MyD88 mediated NF-B, and phosphorylation of PI3K and protein kinase B (PKB, or Akt) (179)

ER/ER ratio and aromatase expression levels as well as 2-hydroxyestrone:16-hydroxyestrone ratios are becoming used as biomarkers to direct phytoestrogen or DIM (diindolylmethane) supplementation, whereas the NF-B, STAT3 and PI3K/Akt phosphorylation status potentially indicating curcumin, resveratrol or polyphenols use for chemosensitizing

However, a compelling argument can be made for oral BPC-157

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