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154,156 It also regulates cellular lipid metabolism by directly phosphorylating acetyl-CoA carboxylase (ACC)1 and ACC2, thereby inhibiting fatty acid synthesis and promoting FAO

This was associated with increased anxiety-like behaviors as well as decreased KDM6B occupancy and increased H3K27me3 occupancy at the Arc synaptic activity response element (SARE) site and promoter

Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested

This enhanced synchronization probably results from phase-locked action-potential firing within the motor cortexbasal ganglia circuit 65

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