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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide

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This mechanism allows scientists to study fat metabolism independently from full-length growth hormone , isolating the peptides lipolytic effects

GLP-1 receptor agonists like semaglutide and tirzepatide reduce appetite centrally while improving insulin sensitivity

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