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Small but sufficient amounts of 2,3-BPG are found in most cells, with the notable exception of red blood cells, where it is synthesized through the RapoportLuebering shunt

Numerous studies have shown a connection between oral bacteria and the gut-microbiota axis and various gastrointestinal ailments, including Crohns disease, ulcerative colitis, inflammatory bowel disease, liver diseases, hepatocellular and pancreatic ductal carcinoma, and many more [72]