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As renal cells age, they accumulate mitochondrial dysfunction, leading to cytosolic DNA leakage that likely activates the cGAS-STING pathway and NF-B signaling

Khavinson, V., et al

The compound targets the substrate-binding site of NNMT and has been characterized in in-vitro enzyme-inhibition and cell-based studies

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Dakin SG, Smith RKW, Heinegrd D et al (2014) Proteomic analysis of tendon extracellular matrix reveals disease stage-specific fragmentation and differential cleavage of COMP (cartilage oligomeric matrix protein)