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Nicotinamide N-methyltransferase as a potential therapeutic target in metabolic and related diseases

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Specifically, diet-induced obese (DIO) mice exhibited diminished NAD + levels and impaired postprandial glucose metabolism compared to their lean counterparts

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Nicotinamide N-methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine (SAH)