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Units on a U-100 insulin syringe = (Dose in mg Concentration in mg/mL) 100 *These conversions dont land on a clean syringe marking

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

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Hallak H, Seiler AEM, Green JS et al (2000) Association of heterotrimeric Gi with the insulin-like growth factor-I receptor: release of G subunits upon receptor activation

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