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In the phase 1 study, of 32 healthy male subjects, the 10 mg and 20 mg doses of PT-141 resulted in a significantly greater duration of base rigidity 80%

34 Bergh JJ, Lin HY, Lansing L, Mohamed SN, Davis FB, Mousa S, et al

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The impairment of these physiological aspects leads to excess ROS generation, when exposed to prolonged or extreme levels of drought stress (Hasanuzzaman et al., 2017