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To account for possible selection bias, we used within-individual analyses (similar to prior studies on psychotropic drug use [11, 22, 23]) to adjust for confounders that remained constant within each patient during follow-up, including both observed confounders (e.g., demographics) and unobserved confounders that were not available in our data (e.g., genetic profile, intrinsic treatment adherence, illness severity)

Renal effects : In patients treated with NSAIDs, isolated cases of papillar necrosis and interstitial nephritis have been described

the 1.0mg group reached 12.8%

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