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Glutamate dehydrogenase (GDH) and aspartate aminotransferase (AAT) catalyze the reversible reaction between glutamate and -ketoglutarate (-KG) before the incorporation of glutamate into the TCA cycle ( Figure 1A ) ( Figure 1 Compared to normal cells, cancer cells are characterized by the rapid proliferation of cells, followed by a highly active metabolism ( 1.1 Glutamate receptors and tumor microenvironment Cancer cells with different types of cells such as endothelial cells, fibroblasts, immune cells, and extracellular components ( The role of glutamate in the regulation of the metabolism in the TCA cycle has been amply investigated previously and reviewed ( Figure 1B ) [See references ( Figure 1 summarizes the different roles of glutamate in the cell)

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(2) Immunosuppression and immune evasion

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GPR65 contributes to constructing immunosuppressive microenvironment in glioma