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Fortunately, in view of the potential threat to oxygen delivery that methemoglobin poses, there are protective mechanisms that ensure that most of this methemoglobin is converted back to hemoglobin, so that no more than 1-2 % of total hemoglobin is normally present as methemoglobin

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Notably, a premature shift of neural stem cells away from neuronogenesis and to gliogenesis seems to play a leading role in several syndromes

Patients were stratified into first-line (n=149) and higher-line (n=82) groups