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revealed that CDKN2A deletion reshaped the lipidome of GBM, redistributing oxidative PUFAs to distinct lipid compartments, thereby increasing lipid peroxidation levels and significantly increasing sensitivity to ferroptosis ( in vivo ( 2.3 Imbalance of the antioxidant defense system The occurrence of ferroptosis in GBM cells not only depends on the activation of death signaling but is also closely related to the functional imbalance of the endogenous antioxidant defense system

Am J Clin Nutr 88, 398406.CrossRefGoogle ScholarPubMed Seddon, JM, George, S, Rosner, B (2006) Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of age-related macular degeneration