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Gout is caused by a buildup of uric acid in the body and leads to sudden, intense pain and swollen joints that become red and hot

Therefore, exploration of aging mechanisms is not only conducive to clarifying the pathological basis of age-related diseases but also provides new targets and ideas for the development of anti-aging treatment strategies

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This metabolic pathway is essential for producing ribose-5-phosphate , which is needed to synthesize nucleotides, and NADPH , an energy-carrying molecule vital for various biological processes, including cholesterol and fatty acid synthesis, respiratory burst, regenerating glutathione, and metabolizing large quantities of alcohol and heme

Cells were allowed to migrate for 4 h at 37 C in an atmosphere of 95% air/5% CO 2