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This concentration-dependent effect is epitomized in energy metabolism during exercise, where a shift from white adipose tissue to intramuscular triglycerides as the primary fatty acid source occurs as blood lactate rises from 2 mM to 5 mM, demonstrating lactates role as a metabolic rheostat in real-time [148]

Overall, evidence suggests that GHSR1as constitutive activity is not required for the alteration in D2R-mediated signaling

10.1111/j.1528-1167.2010.02612.x 23 EsmonC

PLoS ONE 10, e0136137

However, in GSC, 5 mM NAC does not help reverse the cytotoxicity of elesclomol, while 10 mM NAC only has a partial reversal effect (139)