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Therefore, the future of ferroptosis-targeted therapy depends not only on discovering new inhibitors or inducers but also on solving the core issues of how to deliver the right drug to the right brain region in the right patient and how to reliably monitor ferroptosis in clinical settings

Dysfunctional ENaCs have been implicated in Liddle syndrome, pseudohypoaldosteronism, cystic fibrosis, and may contribute to salt-sensitive hypertension [15]

Consequently, calcitriol is regarded as a steroid hormone and reacts with the associated vitamin D receptor (VDR) in a similar way to other steroid hormones with their respective intracellular receptors [141]

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This protein forms dimers or higher oligomers and adopts an extended conformation containing both -helix and -sheet structures