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In the purine pathway, in addition to uric acid, studies have also identified inosine, an endogenous purine, as capable of downregulating the TNF-, IL-1, IL-6, and Macrophage inflammatory protein-2 (MIP-2) expression induced by LPS, and reducing MIP-1 (Figure 4)

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NDD-CKD patients in this study had significantly lower hemoglobin (Hb) concentrations (12.4 [11.113.7] g/dL) than healthy controls (13.8 [13.014.8] g/dL, P 1.7, history of peritonitis) did not influence eryptosis

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