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If the FDA decides to place encapsulated mercury fillings into Class III, FDA should place restrictions (not special controls or recommendations) on the use of this material in children ages 0-19, women of childbearing age, people with compromised kidney, immune, and neurological function, those who are hypersensitive to mercury, those who test positive for apolipoprotein E4 or coproporphyrinogen oxidase (CPOX4), and other persons within susceptible subpopulations as described herein

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In general, three phases of metabolic detoxification of xenobiotics have been often described in the literature