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4.4.4 Integrative perspective: convergent and divergent metabolic fates of amino acids in DKD The preceding sections delineate distinct metabolic trajectories for aromatic amino acids (AAA), branched-chain amino acids (BCAA), and sulfur-containing amino acids (SAA) within the gut-liver-kidney axis

Lyophilisation removes water under low pressure, preserving the peptide structure and increasing shelf life

It must then bind to intrinsic factor for absorption in the intestines

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However, the rate of weight regain was faster after WMMs than after BWMPs and greater initial weight loss was typically associated with faster weight regain.11 Nevertheless, in our sensitivity analysis (fig 4), we still observed faster weight regain after WMM for a fixed amount of initial weight loss