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doi: 10.1016/j.taap.2023.116658 52

The P2X7 receptor is involved in inflammation triggered by SiO 2 and TiO 2 UFPs by increasing IL-1 secretion, likely through the inflammasome pathway 91

In this process thiol groups (-SH) would be oxidized to disulfide (-S-S) very fast, so using a reducing substance such as sodium borohydride (NaBH 4 ) before derivatization of thiol group is essential

2 Methods 2.1 Literature search and analysis We searched the PubMed database from January 1 st , 2000, to April 30 th , 2021, with logical combinations of the following terms (in English only): levothyrox*, LT4, L-T4, liothyronin*, T3, tetraiodothyro*, triiodothyro*, absorp*, absorb*, distrib*, transport*, metabol*, eliminat*, excret*, deiodinase*, bioavailab*, titrat*, food*, interacti*, and enterohepat*