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doi: 10.1002/acn3.51004 222 GandyKAOZhangJNagarkattiPNagarkattiM

The positive surface charge of NPs, due to presence of N-[1-(2, 3-dioleoyloxy) propyl]-N, N, N-trimethylammonium salt (DOTAP), is accountable for mucoadhesion and the sluggish penetration of the NEs across the respiratory mucosa and into adjacent blood vasculature

Fold changes relative to WT C2C12 cells are shown

In a study on melanoma cells, baicalin-loaded PLGA NPs containing an antigenic peptide and a toll-like receptor (TLR)-9 agonist coated with a galactose-inserted erythrocyte membrane showed remarkable inhibitory effects on melanoma tumor cells [98]