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Inhibition of xanthine oxidase (XO) may cause increased plasma concentrations of azathioprine or its metabolites leading to toxicity (see PRECAUTIONS: Drug Interactions)

A deficiency in this vital nutrient can lead to a range of health issues, such as fatigue, memory impairment, mood swings, and, in severe cases, neurological changes

According to the anti-cancer mechanisms and chemical structure, chemotherapeutic agents are classified as alkylating agents, such as cyclophosphamide (CYP) and methotrexate

Preincubation with copper sulfate increases its toxic effects on neurons (Sinopoli et al., 2014)

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