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This replacement completely abolished the TOP2-mediated DNA cleavage induced by thiol-reactive quinones

Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

Similar effects are seen with another major cell cycle inhibitor CDKN2A/p16 INK4a , where decreased levels can result in platinum resistance, while in other cases, result in platinum sensitivity (Supplementary Table S1)

These substances (at 0.41.0 g/kg) have demonstrated a high ability to protect neuronal cells, reduce lipid oxidation, and reduce apoptosis in C

specifically, ATF4 overexpression increased the number and length of tumor vessels, and ATF4 knockdown led to the opposite effect (76)