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When the intestinal barrier function is impaired, microbial products such as LPS, bacterial DNA, and peptidoglycan can enter the bloodstream and migrate to the lungs, activating local immune responses through TLRs (152154)

Studies have shown that the development of DKD is associated with defective renal autophagy (119, 136140)

Chakravarty, A., Hinrichsen, J., Whittaker, L

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Likewise, the use of Kanjangs (Fermented Soy Sauce and Sesame Sauce) exerted an anticolitic effect partially by reducing the serum levels of proinflammatory cytokines and inhibiting the mRNA expression of these factors in the colon tissue of DSS-induced C57BL/6 mice of UC [467]