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Pediatric pharmacokinetics and long-term safety require clarification, particularly for polyphenols and carotenoids with intrinsically low oral bioavailability and potential interactions with conventional medications like antipsychotics or stimulants (Hendouei et al., 2020

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Small, uncontrolled, open-label intervention studies have suggested a beneficial effect of acetyl-L-carnitine (ALCAR) in patients with painful neuropathies