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We noticed, however, that the bottom part of subpocket C in the vicinity of the fragments found in the X-ray structures is formed by the hydrophobic portions of D325, Y479, A481, H538, G483, V469, T471 and is likely to prefer bulky hydrophobic substituents

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If this is true, if I can show this is true in the study, I think we could use it in the corporate world to leverage some universal five days in the mountains for the five-day retreat once a month in the mountains or whatever