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Also valine has been proven important for the oxidation of the reduced flavin by molecular oxygen in choline oxidase and it has been reported that replacement of Val464 with alanine in the enzyme results in a twofold decrease in the limiting rate constant for flavin reduction (k red ) and less than fivefold decrease in the equilibrium constant for formation of the enzymesubstrate complex (K d ) 52

In addition, greater TMEM106B pathology has been observed in FTLD- GRN and LATE-NC cases [160, 163]

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First, we will describe the mechanisms of action of the major active ingredients in functional foods in preventing and suppressing tumors, including their intervention in cancer development through antioxidant, anti-inflammatory, apoptosis-inducing, and tumor proliferation and metastasis-inhibiting pathways (Figure 2)