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Selenium and epigenetics in cancer: focus on DNA methylation

CM-272 inhibits G9a, DNMT1, DNMT3A, and DNMT3B with an IC 50 of 8 nM, 382 nM, 85 nM, and 1,200 nM, respectively (Figure 8), and promotes the apoptosis of various tumor cells in vitro

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Access this article Similar content being viewed by others Abbreviations AMPA: Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid CNS: Central nervous system DC: Dendritic cell EAE: Experimental autoimmune encephalomyelitis GluR: Glutamate receptors iGluRs: Ionotropic glutamate receptors Kainate: 2-carboxy-3-carboxymethyl-4-isopropenylpyrrolidine mGluRs: Metabotropic glutamate receptors MS: Multiple Sclerosis NMDA: N-methyl-d-aspartate Teff: Effector T cell Treg: Regulatory T cell Th: Helper T cell References Affaticati P, Mignen O, Jambou F, Potier MC, Klingel-Schmitt I, Degrouard J, Peineau S, Gouadon E, Collingridge GL, Liblau R, Capiod T, Cohen-Kaminsky S (2011) Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells