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Notably, the serine peptidase kumamolysin from Alicyclobacillus sendaiensis has undergone multiple generations of computational redesign and optimisation (Kuma030, Kuma062, TAK-062, and KumaMax) (Pultz et al, 2021

10.1016/j.sbi.2019.07.012 218 LuJ.HolmgrenA

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