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The United States Pharmacopeia (USP) has established monographs defining the specifications for bacteriostatic water, including benzyl alcohol concentration, sterility testing requirements, and endotoxin limits

Several clinical trials have demonstrated the efficacy of amantadine in reducing motor fluctuations in PD patients treated with levodopa [41]

The only reliable contamination prevention is strict adherence to refrigerated storage (28C), aseptic needle technique, and discarding vials after 28 days regardless of appearance