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1 DVT can lead to complications such as varicose veins, rapid heartbeat, heart failure, and more commonly, pulmonary embolism 2 (Figure 1)

The lentiviral particles for CBS OPT and L2HGDH OPT constructs were generated similarly with the packaging system as those for sgRNA but selected with puromycin at a final concentration of 1.5 g/ml