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Although randomized placebo-controlled studies are regarded as the gold standard in the validation of the safety and efficacy of therapies, given the fact that the occurrence of a pregnancy is a multifactorial process mainly determined by the genomic quality of the egg, to show the impact of antioxidant therapy on pregnancy outcome in randomized placebo-controlled studies would be unrealistic and extremely difficult to perform

Furthermore, a negative significant correlation was revealed between NAAG and the GSRS subscale for constipation

A cause-and-effect relationship has not been established but some striking associations were recently found based on consumption levels

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Some protocols require daily injections